PENGGUNAAN SCIATIC FUNCTIONAL INDEX (SFI) DAN TIBIAL FUNCTIONAL INDEX (TFI) DALAM PENILAIAN REGENERASI MOTORIS SARAF TEPI
Abstract
Regenerasi motorik saraf tepi dapat dinilai dengan menggunakan Sciatic Function Index (SFI) dan Tibial Function Index (TFI). Namun, studi komprehensif mengenai aspek anatomi dan metodologis pengukuran belum memadai. Penelitian ini bertujuan membandingkan penggunaan TFI dan SFI dalam menilai pemulihan fungsi motorik saraf tepi. Penelitian ini menggunakan desain posttest only with control group. Delapan belas tikus Wistar jantan dibagi menjadi tiga kelompok. Kelompok I, nervus ischiadicus dicederai 5mm proksimal terhadapat bifurkasi nervus ischiadicus kaki belakang kanan. Kelompok II, nervus tibialis dicederai 5mm proksimal dari tempat bercabang nervus cutaneous surae medialis kaki belakang kanan dan kelompok III sebagai kontrol negatif. SFI dan TFI diamati pada minggu II, IV, VI, dan VIII dan dianalisis. Hasil penelitian ini menunjukkan terdapat perbedaan yang signifikan antara nilai varians SFI dan TFI pada pengamatan minggu III, IV, dan VI (p-value < 0,05). Penggunaan TFI sebagai metode penilaian regenerasi motorik saraf tepi lebih baik dari pada penggunaan SFI yang ditunjukkan oleh nilai varians yang lebih kecil.
References
Novak CB, Anastakis DJ, Beaton DE, Mackinnon, SE, Katz, J. Biomedical and psychosocial factors associated with disability after peripheral nerve injury. Journal of Bone Joint Surgery American 2011; 93(10):929-36.
Amado S, Simoes MJ, Armada da Silva PAS, Luis AL, Shirosaki Y, Lopes MA, Santos JD, Fregnan F, Gambarrota G, Raimondo S, Fornaro M, Veloso AP, Varejao ASP. Use of Hybride Chitosan Membranes and N1E-115 Cells for Promoting Nerve RegenerationinAnAxonotmesis Rat Model. Biomat 2008; 29:4409-4419.
Retno-Ardhani, Susilowati R, Ana ID. Functional recovery of sciatic nerve on application of gelatine hydrogel membrane and platelet-rich plasma. Proceeding Foril X 2011 Faculty of Dentistry Trisakti University; 2011 December 6-8th; Jakarta, Indonesia, 2011.
Kanaya F, Firrell JC, Breidenbach WC. Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometryasindicators of regeneration. Plast Reconstr Surg 1996; 98:1264-71.
Inserra MM, Bloch DA, Terris DJ, 1998. Functional indices for sciatic, peroneal, and posterior tibial nerve lesions in the mouse. Microsurg 1998; 18:119-124.
Rodinskii AG, Serdyuchenko IY, Demchenko ТV. Functional reinnervation of the distal hindlimb muscles in rats after compression of the sciatic nerve. Neurophysiology 2011; 42(5):405-417.
Ugrenovic S, Jovanovic I, Krstic V, Stojanovic V, Vasovic L, Antic S, Pavlovic S. The level of sciatic nerve division and its relations to the piriform muscle. Abstract Vojnosanit Pregl 2005; 62:45–49.
Sarikcioglu L, Demirel BM, Utuk A. Waking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat. Folia Morphol 2008; 68(1):1-7.
Rupp A, Schmahl W, Lederer W, Matiasek K. Strain differeces in the branching of the sciatic nerve in rats. Anat Histo Embyol 2007; 36:202-208.
Strasberg JE, Strasberg S, Mackinnon SE, Watanabe O, Hunter DA, Tarasidis G. Strain differences in peripheral nerve regeneration. J Reconstr Microsurg 1999; 15:287–293.
Varajao ASP, Meek MF, Ferreira AJA, Patricio JAB, Cabrita AMS. Function evaluation of peripheral nerve regeneration in the rat: walking track analysis. J Neurosci Meth 2001; 108:1-9.
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