ANALISIS PEMERIKSAAN LABORATORIUM PADA KASUS LEPTOSPIROSIS DISERTAI ABSES HATI AMOEBA
DOI:
https://doi.org/10.36341/cmj.v3i3.1657Kata Kunci:
amoebic liver abscess, leptospirosis, laboratory examinationAbstrak
Leptospirosis is a disease caused by spirochaeta microorganism of the genus Leptospira, while the amoebic liver abscess is an extraintestinal complication by Entamoeba Histolytica. Both diseases occurred in a 45-year-old man with poor personal hygiene and environment sanitation. Amoebic liver abscess was found to be a coincidence that was thought to have existed before the patient developed leptospirosis so that the two diseases caused overlapping clinical manifestations in the patient, but the acute symptoms experienced by the patient at the time of admission were more likely to be caused by his leptospirosis. Patient complained of high fever, yellowing of the skin and eyes, urinating like concentrated tea, stiffness in both legs, nausea, vomiting and heartburn. On physical examination found febrile, tachycardia, icteric on skin and sclera, ciliary injection, and hepatomegaly. Laboratory tests showed mild anemia with normocytic normochromic features, leukocytosis with neutrophilia shift to the right, thrombocytosis, increased ESR, prolonged APTT, hyperbilirubinemia, elevated SGOT SGPT, ALP and GGT enzymes, hypoalbuminemia, hyperglobulinemia, and bilirubinuria. Microscopic examination with negative staining of urine samples found Leptospira. Abdominal ultrasound examination showed a solitary space occupying lesion (SOL) in the right lobe of the liver and on serological examination showed positive antiamoeba. Based on the above, this patient was diagnosed as having coincident leptospirosis with amoebic liver abscess.
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Referensi
[2] K. V. Evangelista and J. Coburn, “Leptospira as An Emerging Pathogen: A Review of Its Biology, Pathogenesis and Host Immune Responses,†Future Microbiol., vol. 5, no. 9, pp. 1413–1425, 2010.
[3] Zein U, “Leptospirosis,†pada Buku Ajar Ilmu Penyakit Dalam, Jakarta: Penerbit FKUI, 2009
[4] L. J. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Harrison’s Principles of Internal Medicine, 18th Edition, USA: McGraw Hill, 2012.
[5] Ryan KJ & Ray CG, “Sherris Medical Microbiology, USA: McGraw Hill, 2004.
[6] Levett DN, “Leptospira,†in Principles and Practice of Clinical Bacteriology Editors, England : John Wiley & Sons, 2006.
[7] A. J. Shetty N, Tang JW, Infectious Disease : Pathogenesis, Prevention and Case Studies, United Kingdom: Wiley Blackwel, 2009.
[8] Sharma MP & Ahuja V, “Amoebic liver abscess,†J. Indian Acad. Clin. Med., vol. 4, no. 2, pp. 107–111, 2003.
[9] M. G. Netea, B. J. Kullberg, and J. W. M. Van der Meer, “Circulating cytokines as mediators of fever,†Clin. Infect. Dis., vol. 31, no. SUPPL. 5, pp. 178–184, 2000.
[10] R. W. Bauman, E. Machunis-Masuoka, and J. E. Montgomery, Microbiology: With Diseases by Body System, USA: Benjamin Cumming, 2012.
[11] Bonheur JL, “Biliary obstruction,†2015. [Online]. Available: www.emedicine.medscape.com. [Accessed: 20-Dec-2015].
[12] Y. KS, B. AK, and R. K, “Serum Creatinine Phosphokinase [Cpk] an Early Marker in Human Leptospirosis,†Int. J. Med. Clin. Res., vol. 2, no. 2, pp. 29–33, 2011.
[13] A. Verma and B. Stevenson, “Leptospiral Uveitis - There Is More to It Than Meets the Eye!,†Zoonoses Public Health, vol. 59, no. SUPPL.2, pp. 132–141, 2012.
[14] M. B. Viana, “Anemia and infection: A complex relationship,†Rev. Bras. Hematol. Hemoter., vol. 33, no. 2, pp. 90–91, 2011.
[15] S. H. Lee, S. Kim, S. C. Park, and M. J. Kim, “Cytotoxic activities of Leptospira interrogans hemolysin SphH as a pore-forming protein on mammalian cells,†Infect. Immun., vol. 70, no. 1, pp. 315–322, 2002.
[16] Kresno SB, Imunologi : Diagnosis dan Prosedur Laboratorium, Edisi Kelima. Jakarta: Badan Penerbit FKUI, 2010.
[17] K. Nakada-Tsukui and T. Nozaki, “Immune response of amebiasis and immune evasion by Entamoeba histolytica,†Front. Immunol., vol. 7, no. MAY, pp. 1–13, 2016.
[18] J. L. Chen and K. Afsari, “Reactive thrombocytosis caused by infection,†Infections in Medicine, vol. 19, no. 10. pp. 480–483, 2002.
[19] J. F. P. Wagenaar et al., “Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality,†Trop. Med. Int. Heal., vol. 15, no. 2, pp. 152–159, 2010.
[20] Guyton AC & Hall JE, Textbook of Medical Physiology, Eleventh Edition. USA: Elsevier Saunders, 2006.
[21] M. Younes-Ibrahim et al., “Na,K-ATPase: A molecular target for Leptospira interrogans endotoxin,†Brazilian J. Med. Biol. Res., vol. 30, no. 2, pp. 213–223, 1997.
[22] N. S. Jain S, Gautam V, “Acute Phase Proteins: As Diagnostic Tool,†J Pharm Bioallied Sci, vol. 3, no. 1, pp. 118–127, 2011.
[23] Don BR & Kaysen G, “Serum Albumin: Relationship to Inflammation and Nutrition,†Semin. Dyalisis, vol. 17, no. 6, pp. 432–437, 2004.
[24] M. P. Hoffbrand AV, Pettit JE, Essential Haematology, Fourth Edition. USA: Blackwell Science, 2001.
[25] A. Cosme, E. Ojeda, I. Zamarreño, L. Bujanda, G. Garmendia, M. J. EcheverrÃa et al., “Pyogenic versus amoebic liver abscesses. A comparative clinical study in a series of 58 patients,†Rev. Esp. Enfermedades Dig., vol. 102, no. 2, pp. 90–99, 2010.
[26] J. Cheriyan and M. J. Brown, “Primary prevention of CVD : treating hypertension Search date December 2007 Cardiovascular disorders Primary prevention of CVD : treating hypertension,†Cardiovasc. Disord., no. December 2009, pp. 1–20, 2010.
[27] I. Çetin, B. Yildirim, Ş. Şahin, I. Şahin, and I. Etikan, “Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat,†Turkish J. Med. Sci., vol. 40, no. 5, pp. 771–782, 2010.
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