• May Valzon Universitas Abdurrab
  • Widya Rizkika Islami Universitas Abdurrab


Indonesia is one of the countries that often experiences large-scale forest and peatland fires. The biggest disaster after the tsunami that occurred in Indonesia has occurred since the last dozen years, especially in Riau, Kalimantan. The smoke produced from these forest fires can worsen the air which will be inhaled and entered through the lungs so that it can enter the blood vessels and circulate throughout the body. It gives a direct effect by some of the components contained in the particles, such as endothelial damage to blood vessels due to particulate matter. Short-term exposure will cause acute atherothrombosis, ischemia, regulation of the inflammatory response as well as a decrease in blood vessel diameter. Meanwhile, long-term effects will occur such as local inflammation to atherogenesis. This study aims to analyze changes in the diameter of the aortic lumen and the presence or absence of endothelial foam cells. using a true experimental study with a posttest approach with control group on 6 mice that received exposure to fire smoke, 6 mice that did not get exposure or as a control for 10 days. Based on Fisher's test, it was found that exposure to peat burning smoke for 10 days caused the formation of foam cells on the aortic wall.

Keywords: Fire smoke, aortic diameter, foam cells, peat, Fire Smoke, Aortic Diameter, Foam Cells, Peat


[1] A. Krasovskii et al., “Modeling burned areas in Indonesia: The FLAM approach,” Forests, vol. 9, no. 7, 2018,
[2] E. Rianawati, “Working Paper Series,” Review, vol. 85, no. 6, pp. 1–14, 2015,
[3] Kemenkes RI, “InfoDATIN Masalah Kesehatan Akibat Kabut Asap Kebakaran Hutan dan Lahan.” pp. 1–8, 2015.
[4] S. Sagala, E. Sitinjak, and D. Yamin, “Importance of Community Preparedness to Wildfire in Indonesia,” Review, vol. 85, no. 6, pp. 1–22, 2013,
[5] G. BNPB, Karhutla Riau, Ini Pembakaran Bukan Kebakaran, vol. 5, no. 1. 2014.
[6] A. G. Rappold et al., “Peat bog wildfire smoke exposure in rural North Carolina is associated with cardiopulmonary emergency department visits assessed through syndromic surveillance,” Environ. Health Perspect., vol. 119, no. 10, pp. 1415–1420, 2011,
[7] M. [Director Wayne E. Cascio, “Wildland fire smoke and human health,” pp. 1–26, 2019,
[8] C. Wang, Y. Tu, Z. Yu, and R. Lu, “PM 2 . 5 and Cardiovascular Diseases in the Elderly : An Overview,” pp. 8187–8197, 2015, doi: 10.3390/ijerph120708187.
[9] M. Smaratungga, R. C, I. AR, and M. JW, “Perbedaan kadar prolylcarboxypeptidase di pasien sindrom koroner akut dengan pasien angina pectoris,” J. Clin. Ligand Assay, vol. 22, no. 1–2, pp. 55–58, 2015.
[10] A. T. and A. C. M. Franchini , A. Guida, “Air pollution , vascular disease and thrombosis : linking clinical data and pathogenic mechanisms,” pp. 2438–2451, 2012, doi: 10.1111/jth.12006.
[11] L. Nazlyza, “Gambaran Histopatologi Aorta Tikus Wistar Yang Terpapar Asap Rokok,” J. e-Biomedik, vol. 1, no. 2, pp. 1019–1022, 2014, doi: 10.35790/ebm.1.2.2013.3654.
[12] B. Messner and D. Bernhard, “Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis,” Arterioscler. Thromb. Vasc. Biol., vol. 34, no. 3, pp. 509–515, 2014,
[13] R. G. Jaldin, E. Castardelli, J. E. Perobelli, and W. B. Yoshida, “Morphologic and Biomechanical Changes of Thoracic and Abdominal Aorta in a Rat Model of Cigarette Smoke Exposure,” vol. 27, pp. 791–800, 2013.
[14] K. N. Berawi and T. Agverianti, “Efek aktivitas fisik pada proses pembentukan radikal bebas sebagai faktor risiko aterosklerosis,” J. Major., vol. 6, no. 2, pp. 86–91, 2017, [Online]. Available:
[15] D. Mutiasari and R. Muhyi, “Pengaruh Lama Paparan Asap Terhadap Risiko Aterosklerosis Melalui Pengukuran Malonildealdehyde Dan Advanced Oxidation,” pp. 149–157, 2020.
[16] A. A. Hamid, L. A. Usman, S. E. Elaigwu, and M. F. Zubair, “Environmental and health risk of bush burning,” Adv. Environ. Biol., vol. 4, no. 2, pp. 241–249, 2010.
[17] O. Aztatzi-Aguilar et al., “Exposure to ambient particulate matter induces oxidative stress in lung and aorta in a size- and time-dependent manner in rats,” Toxicol. Res. Appl., vol. 2, p. 239784731879485, 2018, doi: 10.1177/2397847318794859.
[18] N. J. N. N. P. S. Daniel E Shumer, “Ultrafine Particulate Matter Exposure Impairs Vasorelaxant Response in Superoxide Dismutase 2 Deficient Murine Aortic Rings,” Physiol. Behav., vol. 176, no. 12, pp. 139–148, 2017,
[19] A. Ayu and M. Adi, “Perubahan Histopatologi Otot Jantung dan Aorta Mencit Jantan Pascapaparan Asap Rokok Elektrik Exposure To Electric Cigarette Smoke ),” Vol. 8, No. 4, pp. 541–551, 2019, doi: 10.19087/imv.2019.8.4.541.
[20] J. P. Langrish et al., “Cardiovascular effects of particulate air pollution exposure: Time course and underlying mechanisms,” J. Intern. Med., vol. 272, no. 3,
[21] Z. Khasanah, “Pengaruh pemberian jus tomat (Lycopersicon esculentum Mill.) Terhadap kadar malondialdehida (MDA) dan gambaran histologi pembuluh darah jantung mencit (Mus musculus) yang dipapar asap rokok,
[22] C. G. Santos-Gallego, B. Picatoste, and J. J. Badimón, “Pathophysiology of acute coronary syndrome,” Curr. Atheroscler. Rep., vol. 16, no. 4, 2014,
[23] Y. V. Bobryshev, E. A. Ivanova, D. A. Chistiakov, N. G. Nikiforov, and A. N. Orekhov, “Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis,” Biomed Res. Int., vol. 2016, no. Figure 1, 2016,
[24] A. N. Orekhov et al., “Signaling Pathways Potentially Responsible for Foam Cell Formation : Cholesterol Accumulation or Inflammatory Response — What is First ?,” 2020.
[25] N. Yunita, A. Fitriyah, Y. Amalia, and Y. Purnomo, “Efek Ekstrak Etanol Daun Gedi Merah ( Abelmoschus Manihot ( L .) Medik ) Terhadap Kadar Tnf-Alfa Jaringan Dan Diameter Lumen Aorta Tikus Model Diabetes Melitus Effect Of Ethanol Extract Of Abelmoschus Manihot ( L .) Medik On Tissue Tnf-Alfa Levels And Aor,” no. 0341, pp. 140–146.
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