Jurnal Ilmu Kesehatan Abdurrab

Evaluation Of Suitability Level Of Drug Storage In Pharmacy Warehouse Regional General Hospital Prof.Dr.Ma Hanafiah SM Batusangkar

Sisri Novrita, Berti Wila Rilisa, Isra Reslina3 — Sun, 31 Mar 2024 00:00:00 +0700

Drug management is an important aspect in improving the quality of hospital services, to support the smooth process of pharmaceutical services and to ensure the quality of pharmaceutical preparations. Hospital service standards include clinical pharmacy service standards and drug management. The purpose of this study was to see whether drug storage in the Prof.Dr.MA Hanafiah SM Batusangkar Hospital warehouse complies with the storage indicators of Permenkes No. 72 of 2016. This research was conducted from February to May in the pharmacy warehouse at Prof.Dr.MA Hanafiah SM Batusangkar Hospital. This research is a non-experimental descriptive research with data collection methods used are interviews and observations based on the standards of the RI Minister of Health No. 72 of 2016 and documentation. Based on the results of the study, it was found that the level of suitability of storage in the pharmaceutical installation warehouse at Prof. Dr. MA Hanafiah SM Batusangkar Hospital was 89% in accordance with Permenkes No 72 of 2016. Meanwhile, logistics management was fairly good with a percentage of conformity of drugs with stock cards of 100%, there were no damaged drugs but there was a percentage of 0,037% expired drugs.

Toxicity Test of 96% Ethanol Extract of Mahkota Dewa Leaves (Phaleria Macrocarpa) using the Brine Shrimp Lethality Test Method

Larysa Fernenda, Kony Putriani, Oksi Apriliani — Tue, 13 Aug 2024 09:07:47 +0700

Mahkota dewa (Phaleria macrocarpa) is a plant from the Thymelaeceae family. This plant contains several active compounds such as alkaloids, flavonoids, steroids, saponins, and tannins, so it has potential as a herbal medicine in Indonesia. This study aims to determine the toxicity of the leaves of the god crown using the Brine Shrimp Lethality Test (BSLT) method. Extraction of the god crown leaves using 96% ethanol solvent with the maceration method was then carried out a phytochemical screening which showed that the sample of the crown god leaf contained alkaloids, flavonoids, steroids, saponins and tannins. Toxicity testing of the ethanol extract of Mahkota Dewa leaves on Artemia salina Leach larvae was divided into 5 test groups, namely 4 treatment groups (concentrations of 250 ppm, 500 ppm, 750 ppm, and 1000 ppm) and 1 control or comparison group (seawater). Each concentration was made in 3 vials including 10 Artemia salina Leach larvae. Observations were made by looking at the death of Artemia salina Leach larvae after 24 hours of treatment. The research results can be seen through probit analysis by calculating the LC₅₀ value. The LC₅₀ value of the ethanol extract of Mahkota Dewa leaves was 7,7090 /mL. This shows that the ethanol extract of Mahkota Dewa leaves has a toxic effect on Artemia salina Leach larvae because the LC₅₀ value is <1000 ppm.

ANTIBACTERIAL ACTIVITY ASSAY FROM EXTRACT OF MATOA LEAVES (Pometia pinnata J.R. Forst. & G. Forst)

Deri Islami, Khoirul Anam Falakhudin, Muslim Suardi — Sun, 31 Mar 2024 00:00:00 +0700

Matoa (Pometia pinnata J.R. Forst. & G. Forst) can be used as traditional medicine. The plant contains secondary metabolite compounds such as flavonoids, tannins, terpenoids and saponins that have the ability to inhibit the mechanism of action of bacteria. The purpose of this study was to determine the antibacterial activity of n-hexane, ethyl acetate and ethanol extracts of Matoa leaves against gram-positive bacteria Staphylococcus aureus and Streptococcus mutans and gram-negative bacteria Escherichia coli and Klebsiella pneumonia at concentrations of 70, 50, 30 and 10% using the disc diffusion method, Ciprofloxacin as a positive control and DMSO as a negative control. Statistical test results on 70% concentration of ethyl acetate extract showed average results on the inhibition diameter of Staphylococcus aureus, Streptococcus mutans, Eschericia coli and Klebsiella pneumenia were 10.63, 13.43, 11.23, and 13.26 mm, respectively. Based on the results of this study, it can be concluded that the n-hexane, ethyl acetate and ethanol extracts of Matoa Leaf (Pometia pinnata J.R. Forst. & G. Forst) have the ability to inhibit the growth of gram-positive bacteria Staphylococcus aureus and Streptococcus mutans and gram negative bacteria Escherichia coli and Klebsiella pneumonia, but in the n-hexane extract of matoa leaves is not able to inhibit the growth of Staphylococcus aureus.

Determination of Salicylic Acid Levels in Anti-Acne Creams Sold in Online Shops and Pharmacies Using UV-Vis Spectrophotometric and Alkalimetric Methods

Subardi Bali, Larysa Fernenda — Sun, 31 Mar 2024 00:00:00 +0700

Cream is a semi-solid preparation, using an emulsion containing not less than 60% water. Salicylic acid, an anti-acne and keratolic agent, is commonly administered topically. This study aims to analyze salicylic acid levels in anti-acne creams sold online and in pharmacies. Quantitative Testing uses UV -Vis Spectrophotometry and Alkalimetry. Quantitative testing using UV-Vis Spectrophotometry, there were 3 samples sold in pharmacies containing salicylic acid with sample levels A 1.568%, B 1.755%, C 0.895%, and samples sold online contained salicylic acid with sample levels D 0.151%. Alkalimetric quantitative testing, 3 samples sold in pharmacies contained salicylic acid with sample levels A 0.71%, B 0.36%, C 0.48%, and samples sold online contained salicylic acid with sample levels D 0, 42 %. Based on BPOM requirements, the permitted level of salicylic acid in cosmetics does not exceed 2%, so the anti-acne cream product meets BPOM requirements. The salicylic acid level was tested using Uv-Vis spectrophotometry and analyzed using Kruskal Wallis with a significance value of 0.00 (P0.05). It was said that the spectrophotometric method influenced determining the salicylic acid level from samples A – D. The salicylic acid level used alkalimetry. Homogeneity test with the Homogeneity of Variances test with a significance value of P (0.104 - 0.05) homogeneous data. Data were analyzed using ANOVA. The results of the One Way Anova test analysis show a significance value of 0.00 (P 0.05), so the salicylic acid levels of samples A – D carried out using alkalimetry show a significant difference between the 4 samples tested.

Evaluasi Kesesuaian Penyimpanan Obat di Instalasi Gudang Farmasi Puskesmas Rambah Pasir Pengaraian Kabupaten Rokan Hulu

Isna Wardaniati, Ermida Diani Hasibuan, Adrian Mulya — Tue, 13 Aug 2024 09:33:26 +0700

Errors in drug storage at the health center can cause the drug to be damaged, resulting in a decrease in the level/potency of the drug so that when consumed by patients it becomes ineffective in therapy. This study aims to evaluate the suitability of the drug storage process in the pharmaceutical warehouse installation of the Rambah Pasir Pengaraian Health Center against the pharmaceutical service standards at the health center. This research is an observational study with a descriptive cross-sectional design with the object of research on pharmaceutical preparations and infrastructure facilities at the Rambah Pasir Pengarian Health Center Warehouse Installation. The results of the study showed that the suitability of facilities was 94.17%, drug storage was 90.9%, drug storage layout was 100% and the level of suitability of recording drug stock cards was 100%. It is concluded that drug storage at the pharmaceutical warehouse installation of the Rambah Pasir Pengaraian Health Center, Rokan Hulu Regency is in accordance with the Regulation of the Minister of Health of the Republic of Indonesia of 2019 concerning Pharmaceutical Service Standards at Puskesmas.

The Effect of Aromatic Ginger Water Immersion on Edema in The Limbs in Third Trimester Pregnant Women

Rini Hariani Ratih, Yusmaharani Yusmaharani — Sun, 31 Mar 2024 00:00:00 +0700

Background: Edema or swelling due to fluid accumulation in the body often occurs in the extremities, especially in the legs, occurring in around 80% of pregnancies. Carrying out therapy by soaking the feet in warm water mixed with galangal is one of the non-medical measures that can be carried out on pregnant women, with ingredients that are easy to get at the nearest shop. The aim of this study was to determine the effect of galangal water immersion on edema in the legs in third trimester pregnant women. The research method uses the Quasy Experiment type of research. The design used is One Group Pre Test and Posttest. This research was conducted at the Pratama Guava Rose Clinic. Tools and materials used kencur and observation sheet. The population in this study was 13 respondents, sampling using Quota sampling, namely a sampling technique based on criteria set by the researcher. The data sources used are primary data and secondary data. Data analysis used univariate and bivariate before carrying out the bivariate test, a parametric test was carried out, namely the normality test of normally distributed data, namely using the T-Dependent test. The research results show the effect of galangal water immersion on edema in the legs in pregnant women in the third trimester. Significance value < 0.005 with P value = 0.001 (Ha accepted). Conclusion There is an effect of galangal water immersion on edema in the legs in third trimester pregnant women at the Pratama Jambu Mawar Clinic

Description of the Side Effects of Chemotherapy Drugs in Breast Cancer Patients at RSUD Arifin Achmad Pekanbaru

Suci Rahma Ningsih, Wahyu Margi Sidoretno — Sun, 31 Mar 2024 00:00:00 +0700

The most prevalent cancer in women, though it can strike men as well, is breast cancer. Breast cancer is brought on by unchecked cell proliferation, which, if uncontrolled, can turn into a malignant tumour. One breast cancer treatment that requires monitoring and careful attention to adverse effects is chemotherapy. Determining the adverse effects of chemotherapy on patients with breast cancer was the goal of this study. This study uses an observational, non-experimental research design that is descriptive and evaluative in nature. Data has been collected from the medical records of 16 patients with 11 chemotherapy medication regimens who satisfied the inclusion criteria and had an initial diagnosis of breast cancer in the July 2023. The seven types of chemotherapy medications that are employed are: paclitaxel, cisplatin, doxorubicin, docetaxel, carboplatin, cyclophosphamide, herzemab, and fonkopec. Docetaxel with carboplatin was the most often prescribed chemotherapeutic medication combination, accounting for 4 individuals (25%). Potential side effects that arise during treatment are mucositis, decreased appetite, nausea and vomiting, alopecia, changes in skin and nail color, myalgia, fatigue, dizziness, weakness and numbness in the legs. The side effects that consistently manifested in all patients (100%) were myalgia, alopecia, and nausea and vomiting, according to the results.

Systematic Literature Review on Presbyacusis

Donny Haryxon, Sri Marhaeni — Sun, 31 Mar 2024 00:00:00 +0700

Presbyacusis, or age-related hearing loss, is a prevalent condition among the elderly, characterized by a gradual decline in hearing sensitivity, particularly for high-frequency sounds. This systematic literature review synthesizes current research on the epidemiology, pathophysiology, risk factors, diagnosis, and management of presbyacusis. The review aims to provide a comprehensive understanding of the condition, its impact on quality of life, and the effectiveness of various interventions.Presbyacusis, age-related hearing loss

Gelatin Transformed from Catfish Skin (Pangasius hypohthalmus) as Gelling Agent in Piroxicam Gel Formulation

Muslim Suardi — Sun, 31 Mar 2024 00:00:00 +0700

Piroxicam is an effective non-steroidal anti-inflammatory drug, but it has serious side effects orally. The research was conducted to formulate piroxicam in gel dosage form using gelatin transformed from catfish skin (Pangasius hypophthalmus) as a gelling agent. Using this ingredient transformed from pig and cow is unacceptable for certain religious adherents. This study aims were to formulate piroxicam gel and determine the release of piroxicam from gel at various concentrations of 0.75, 0.875, and 1%, while innovator product (F4) was used as a positive control. The evaluations performed were organoleptic, homogeneity, pH, spreadability, and release profile. The release of piroxicam from the gel produced was conducted using a modified paddle-type dissolution device equipped with an eggshell membrane placed on a metal disk. The level of piroxicam dissolved was measured using a UV spectrophotometer at λ_max of 356.4 nm. The release kinetics of piroxicam gel formulas F1, F2, F3 and F4 followed zero-order kinetics model. The dissolution efficiency and T90 from formulas F1, F2, F3, and F4 value were highly significant differences (p < 0.01), while the dissolution rate were significant differences (p < 0.05). All of formula fulfill the requirements except spreadability characteristic.