IMUNOPATOLOGI DAN PERSPEKTIF LABORATORIUM KLINIK SARS - COV - 2 : A REVIEW

  • Dian Nurmansyah Akademi Analis Kesehatan Borneo Lestari
  • Aldiana Astuti

Abstract

Severe Acute Respiratory syndrome corona virus 2 ( SARS-Cov-2) is a virus from Nidoviridales family Coronaviridae that causes acute respiratory syndrome in humans. The virus discovered in wuhan, China in mid December 2019 and determined as a global pendemic by WHO The management of the patient becomes crucial in suppressing the mortality rate of patients with positive COVID-19. The actual viral infection is self-limited disease with supportive treatment. Good treatment support requires information and clarity of viral pathogenesis, laboratory results, patient clinical symptoms and in-depth analysis of virus characteristics and the body's immune response to infection

Keywords: Sars-Cov-2, Coronavirus, Imunopathology

References

Benerjee, K. Kulcsar, V. Mirsa, M. Frieman and K. Mossam. 2019. "Bats and coronaviruses," Viruses, vol. I, no. 11.
Cui, F. Li and Z. Shi.2019. "Origin and evolution of pathogenic coronavirus," Nat.Rev. Microiol, vol. I, no. 17, pp. 181 - 192.
Cyranoski.2020. "Did pangolins spread the China coronavirus to people ?," Nature.
Fan, K. Zhao, Z. Shi and P. Zhou.2019. "Bat Coronavirus in China," Viruses, no. 11, p. 210.
Gorbalenya, S. Baker, R. Basic, R. d. Groot, C. Drosten, A. Gulyaeva, B. Haagmans, C. Lauber, A. Leontovich and B. Neumann.2020."Severe acute respiratory syndrome-related coronavirus: The Species and its viruses - A statement of the coronavirus study group," Microbiology.
Guan, Z. Ni, Y. Hu, W. Liang, C. Ou and J. He.2020."Clinical characteristic of coronavirus disease 2019 in China," N Engl J Med.
Huang, Y. Wang and X. Li.2020."Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China," Lancet, no. 395, pp. 497-506.
Ksiazek, D. Erdman, C. Goldsmith, S. Zaki, T. Peret, S. Emery, S. Tong, C. Urbani, J. Comer and W. Lim. 2003. "A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome," N. Engl. J. Med, no. 348, pp. 1953 - 1966.
Liu, X. Xiao, X. Wei, J. Li, J. Yang and H. Tan. 2020 "Composition and divergence of coronavirus spike proteins and host ACE-2 reseptors predict potential intermediate host od SARS-Cov-2," J Med Virol.
Liu and L. Chen.2019. "Evaluation of a commercial colloidal gold assay for detection of influenza A dan B virus in children's respiratory specimens," Fetal Pediatr Pathol, no. 15, pp. 1-6.
Michael, Loeffelholz and Y. Tang. 2020. "Laboratory diagnosis of emerging human coronavirus infections-the state of the art," Emerging Microbes & Infections.
Paraskevis, E. Kostaki, G. Magiornikis, G. Panaiyotakopoulos and S. Tsioddras.2020."Full-genome evolutionary analysis of the novel coronavirus(2019-nCov) rejects the hypothesis of emergence as a result of recent recombination event.," Infect Genet Evol, no. 79, pp. 104-212.
Qin, C. et al.2020. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis. https:// doi.org/10.1093/cid/ciaa248 (2020).
Seguin, L. Galicier, D. Bouthboul, V. Lamiale and E. Azualov.2016. "Pulmonary involvement in patients with hemophagocytic lymphohistiocytis," Chest, no. 149, pp. 1294-301.
Su, W. Shi, J. Liu and J. Zhou. 2016."Epidemiology, Genetic Recombination, and Pathogenesis of Coronavirus," Trends Microbiol, vol. I, no. 24, pp. 490 - 502.
WHO, 2020. [Online].Coronavirus disease (COVID-2019) situation reports," Available: http://www.who.int/emergencies/disease/novel-coronavirus-2019/situationreports. [Accessed 8 April 2020]
Published
2020-12-21
Section
Articles
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