Chitosan-Honey Biomembrane Contributes to the Healing Process of Burn Wound in Male White Rats

Authors

  • Muslim Suardi Fakultas Farmasi dan Ilmu Kesehatan Universitas Abdurrab
  • Wahyu Margi Sidoretno Fakultas Farmasi dan Ilmu Kesehatan Universitas Abdurrab
  • Refika Sukriyani Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang Sumatera Barat Indonesia

Keywords:

Chitosan, honey, biomembrane, wound, healing.

Abstract

 

Chitosan and honey posses antibacterial activity. The research objectives were to prepare chitosan and chitosan honey biomembrane, and evaluate the influence of chitosan and chitosan-honey-PVA biomembrane on burn wound healing in male white rats. The skin irritation was tested on five healthy volunteers. Twenty-four rats were divided into four groups. Burns were induced on the dorsal skin using a 2-cm-diameter metal plate at 80-100 oC for 5 seconds. The burn area was measured on days 3, 5, and 7 after injury. New blood vessels and bullae were observed histopathologically in scar tissue. Irritation was tested on five healthy volunteers. Bullae were observed in 5, 5, 5, 1, and 3 rats in the negative control, chitosan biomembrane, chitosan-honey biomembrane, and positive control (Sterile Amnion Lyophilized) groups, respectively. The wound area on day 5 after treatment was 3.06 ± 0.088, 2.29 ± 0.176, 2.64 ± 0.147, and 2.43 ± 0.201 cm2 for the negative control, positive control, chitosan-PVA biomembrane, and chitosan-honey-PVA biomembrane groups, respectively. No significant difference was found between the positive control and chitosan-honey-PVA biomembrane (p > 0.05). Chitosan-honey-PVA biomembrane contributes to the healing process of burn wounds. 

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Published

2025-02-11

How to Cite

Suardi, M., Sidoretno, W. M., & Sukriyani, R. (2025). Chitosan-Honey Biomembrane Contributes to the Healing Process of Burn Wound in Male White Rats. Jurnal Ilmu Kesehatan Abdurrab, 2(3), 23–34. Retrieved from https://jurnal.univrab.ac.id/index.php/jika/article/view/5769

Issue

Vol. 2 No. 3 (2024): Volume 2 Nomor 3 September 2024

Section

Articles

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