Formulasi dan Aktivitas Antioksidan Krim Astaxanthin dengan Gelatin Kulit Ikan Patin (Pangasius hypophthalmus) sebagai Penstabil
Kata Kunci:
Astaxanthin, DPPH, gelatinAbstrak
Astaxanthin memiliki aktivitas antioksidan, seperti halnya senyawa karatenoid yang lain. Astaxanthin dapat melindungi sel atau jaringan dari kerusakan yang diinduksi stres oksidatif. Penelitian ini bertujuan untuk memformulasikan sediaan krim astaxanthin dengan penambahan gelatin kulit ikan patin sebagai penstabil dan mengevaluasi karakteristik sediaan krim serta melakukan pengujian aktivitas antioksidan astaxanthin dan sediaan krim dengan metode DPPH. Sediaan krim dibuat dengan variasi konsentrasi 0; 0,05; 0,1 dan 0,2% masing-masing diberi nama formula F0, F1, F2, dan F3. Evaluasi sediaan krim meliputi pengamatan organoleptik, uji homogenitas, uji pH, uji daya sebar, dan viskositas. Hasil pemeriksaan organoleptik setiap formula F0, F1, F2, dan F3 berturut-turut yaitu berwarna putih, merah muda, merah dan merah bata, semua formula tidak berbau dan berbentuk semi padat. Uji homogenitas menunjukkan semua sediaan homogen, rentang pH rata-rata sediaan 6,40±0,10 sampai 6,46±0,05 , uji daya sebar antara 5,03±0,05 sampai 5,16±0,15 cm, viskositas 4984±177 sampai 6915±134. Hasil evaluasi sediaan krim astaxanthin tersebut telah memenuhi persyaratan. Pada pengujian aktivitas antioksidan astaxanthin dihasilkan nilai IC50 3766,62 ppm tergolong kategori tidak aktif dan asam askorbat sebagai pembanding memiliki nilai IC50 6,799 ppm tergolong kategori sangat kuat. Pada pengujian antioksidan sediaan krim astaxanthin tidak terdeteksi aktivitas antioksidan dan krim Garnier sebagai pembanding dihasilkan nilai IC50 19512334,96 ppm tergolong kategori tidak aktif.
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