Penetapan Kadar Asam Salisilat Pada Cream Anti Jerawat Yang Dijual Secara Online Shop Dan Di Apotek Menggunakan Metode Spektrofotometri UV-Vis Dan Alkalimetri
Kata Kunci:
Asam Salisilat, Krim, Spektrofotometri UV-Vis, AlkalimetriAbstrak
Krim merupakan sediaan setengah padat, berupa emulsi yang mengandung air tidak kurang dari 60%. Asam salisilat zat anti jerawat sekaligus keratolik umum diberikan secara topikal. Penelitian ini bertujuan menganalisa kadar asam salisilat pada krim anti jerawat yang dijual di online dan apotek. Pengujian Kuantitatif menggunakan Spektrofotometri UV -Vis dan Alkalimetri. Pengujian kuantitatif dengan Spektrofotometri UV-Vis, terdapat 3 sampel yang dijual di apotek mengandung asam salisilat dengan kadar sampel A 1,568%, B 1,755%, C 0,895%, dan sampel yang dijual di Online mengandung asam salisilat dengan kadar sampel D 0,151%. Pengujian kuantitatif secara Alkalimetri, 3 sampel yang dijual di Apotek mengandung asam salisilat dengan kadar sampel A 0,71%, B 0,36%, C 0,48%, dan sampel yang dijual di Online mengandung asam salisilat dengan kadar sampel D 0,42 %. Berdasarkan persyaratan dari BPOM kadar asam salisilat yang diperbolehkan pada kosmetik tidak melebihi dari 2%, sehingga produk krim anti jerawat memenuhi persyaratan dari BPOM. Uji kadar asam salisilat menggunakan spektrofotometri Uv-Vis dan dianalisis menggunakan Kruskal Wallis dengan Hasil nilai signifikansi 0,00 (P0,05) dikatakan metode spektrofotometri ada pengaruh penetapan kadar asam salisilat dari sampel A – D. Uji homogenitas dengan Homogenity of Variances test dengan nilai signifikansi P (0,104 0,05) data homogen dianalisis menggunakan Anova. Hasil analisis uji One Way Anova menunjukkan nilai signifikansi 0,00 (P 0,05) maka kadar asam salisilat dari sampel A – D yang dilakukan dengan alkalimetri menunjukkan adanya pebedaan yang signifikan dari ke 4 sampel yang diuji.
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