A Impact Of Potentially Hepatotoxic Drug Use On Clinical Outcomes In Patients With Liver Cirrhosis
Abstract
Liver cirrhosis is a pathological liver disease characterized by the formation of fibrous tissue and regenerative nodules in liver cells. The potential for hepatotoxicity due to the use of hepatotoxic drugs leads to worsening of the liver disease suffered by these patients. This study aims to assess the impact of using potentially hepatotoxic drugs on patients' clinical outcomes. This study was an observational study with a cross-sectional design. Data were collected retrospectively through the medical records of patients with liver cirrhosis hospitalized in 2021. The clinical outcomes studied were SGOT, SGPT, albumin, total bilirubin and length of hospitalization. The results obtained were tested using the Kruskal-Wallis statistical test. A total of 62 patients with liver cirrhosis met the inclusion criteria as the study sample. The number of potentially hepatotoxic drug prescriptions received by patients based on Likelihood scores with categories A, B, C, D and E was 368 drugs out of 776 total drug prescriptions (47.4%). The most commonly prescribed potentially hepatotoxic drugs were paracetamol, ceftriaxon, and levofloxacin. It can be concluded that potentially hepatotoxic drugs are still prescribed to patients with liver cirrhosis. Age, gender, child pugh-score, number of drugs, and number of potentially hepatotoxic drugs had no significant effect (p>0.1) on SGOT, SGPT, albumin and total bilirubin. However, patients who received more drugs would have a higher.
References
Bjornsson, E.S dan Hoofnagle, J.H, 2015, Categorization of drugs implicated in causing liver injury: critical assessment based on published case reports, Hepatology. Volume 63 hal.590-603.
Cheney, C.P., Goldber, E.M., Chopra, S, 2012, Cirrhosis and Portal Hypertension: an overview. In: Friedman, L.S, Kheffe, E.B. Handbook of Liver Disease. Philadelphia: Elsevier Inc. Pp. 136-148.
Clarasanti, I., Marthen, C.P.W., Bradley, J.W, 2016, Gambaran Enzim Transminase pada Pasien Tuberkulosis Paru yang Diterapi dengan Obat obat Anti Tuberkulosis di RSUP Prof. Dr. R. D. Kandou, Jurnal e-Clinic Vol. 4, No. 1.
Danastri, C.N, 2013, Sirosis hepatis pada pasien dengan riwayat mengkonsumsi alkohol kronik, Medula, Volume 1, Nomor 2.
Dewi, T., Masruhim, M.A., Sulistiarini, M, 2016, Identifikasi Obat Penginduksi Kerusakan Hati Pada Pasien Hepatitis Di Rumah Sakit Abdul Wahab Sjahranie. Dalam Seminar Nasional Kefarmasian Ke-III. Samarinda, 20-21 April 2016. Samarinda. Fakultas Farmasi Universitas Mulawarman.hal 151-157.
Dipiro, J.T., Dipiro, C.V., Wells, B.G., & Scwinghammer, T.L, 2017, Pharmacoteraphy Handbook Tenth Edition, USA : McGraw-Hill Company.
Dotulong, J. F. J., Sapulete, M. R. dan Kandou, G. D, 2015, Hubungan Faktor Risiko Umur, Jenis Kelamin Dan Kepadatan Hunian Dengan Kejadian Penyakit Tb Paru Di Desa Wori Kecamatan Wori, Jurnal Kedokteran Komunitas Dan Tropik, 3(2), pp. 57–65.
Foster, G.R., Irving, W.L., Cheung, M.C, 2016, Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis, J Hepatol. 64:1224-31.
Jagdish, R.K, 2012, Profil pasien sirosis hati di ruang rawat inap penyakit dalam RSUP H. Adam Malik Medan, Medan: Universitas Sumatera Utara.
Leonor, P.P., Iciar, M.L., Pere, V.B., Francesc, P.L., Olga, D.S, 2012, Drug Dosage Recommendations in Patients With Chronic Liver Disease, Rev.esp.enferm.dig. vol. 104(4).
Rasyid, S.A., Armayani, A., Yuniati, Y., Lio, T.M.P, 2020, Analysis of serum glutamic pyruvic transaminase and serum glutamic oxaloacetic traansaminase levels in tuberculosis patients in Kendari City General Hospital, Indonesia, Infect Dis Rep. Volume 12:8737.
Samarang, S., Syukur, S.B., Syamsuddin, F, 2023, Hubungan average length of stay (AVLOS) dengan tingkat kecemasan keluarga pasien di ruangan ICU RSUD Otanaha, Jurnal Ilmu Kesehatan dan Gizi. Volume 1 nomor 2.
Shi, J., Zhang, Y., Gu, W., Cui, B., Xu, M., Yan, Q., Wang, W., Ning, G., Hong, K, 2012, Serum Liver Fatty Acid Binding Protein Levels Correlate Positively With Obesity and Insulin Resistance n Chinese Young Adults, PloS One 7;7(11).
Silaban, B.P., Lumongga, F., Silitonga, H, 2020, Karakteristik Penderita Sirosis Hati:Literatur Review, Jurnal Kedokteran Methodist, vol.13:2.
Steven, L.R., Orlee, R.G., Anna, F.L., Christine, V., Nicole, M.H., Richard, A.S., K.C, 2020, Spectrum of Disease in Children and Adolescents, Journal of the American Heart Association.
Tambunan, A, Mulyadi, Y, Kahtan M.I, 2013, Karakteristik Pasien Sirosis Hati di RSUP Dr. Soedarso Pontianak periode Januari 2008 - Desember 2010, Jurnal Mahasiswa PSPD FK Universitas Tanjungpura 2(1):1-19.
Walayat, S., Martin, D., Patel, J., Ahmed, U., Asghar, M.N., Pai, A.U., Dhillon, S, 2017, The role of albumin in cirrosis: from a hospital perspective, J.Community Intern Med Perspect, Volume 7(1):8-14.
Yoon, H., Shin, H.J., Kim, M.J., Han, S.J., Koh, H., Kim, S., Lee, M.J, 2019, Predicting Gastroesophageal Varices Through Spleen Magnetic Resonance Elastography in Pediatric Liver Fibrosis, World J Gastroenterol, 25(3):367-377.
WHO. 2013. Global Health Estimates Summary Tables: Projection of deaths, by cause,age and sex. http://www.who.int/healthinfo/global_burden_disease/en/.
Zhang, G., Jazwinski, F.A, 2021, Spontaneous Bacterial Peritonitis, JAMA, vol.325(11):1118.
Zhou, W.C., Zhang, Q.B., Qiao, L., 2014, Pathogenesis of Liver Cirrhosis, World Journal of Gastrology, 20(23):7312-7324.
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