Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat

Wira Noviana Suhery; Meiriza Djohari; Novia Risky Nur

doi:10.36341/jops.v7i1.4161

Wira Noviana Suhery Sekolah Tinggi Ilmu Farmasi Riau
Meiriza Djohari Sekolah Tinggi Ilmu Farmasi Riau, Jl. Kamboja, Simpang Baru, Pekanbaru, Indonesia
Novia Risky Nur Sekolah Tinggi Ilmu Farmasi Riau, Jl. Kamboja, Simpang Baru, Pekanbaru, Indonesia

: https://doi.org/10.36341/jops.v7i1.4161

Abstract

The purpose of this study was to determine the effect of oil components of fenofibric acid self nanoemulsifying drug delivery systems. The investigated oils are long chain triglycerides (LCT) and medium chain triglycerides (MCT). The oils used are peanut oil (F1), castor oil (F2), virgin coconut oil (F3), and palm oil (F4). The study showed that the solubility of fenofibric acid in each oil F1 (0.57 ± 0.009 mg/ml), F2 (5.45 ± 0.17 mg/ml), F3 (0.85±0.007 mg/ml), F4 (1.04±0.03 mg/ml. The solubility of fenofibric acid in SNEDDS; F1 (27.72±0.54 mg/ml), F2 (35.50±0.96mg/ml), F3 (29.58±0.47 mg/ml), and F4 (32.14±0.44 mg/ml). The different spontaneous emulsification times were F1 (146.51 ± 2.85 seconds), F2 (37.11 ± 1.83 seconds), F3 (99.98 ± 0.63 seconds), and F4 (56.40 ± 1.71 seconds), and the results of dissolution at 60 minutes are F1 (73.66 ± 0.56%), F2 (96.52 ± 0.34%), F3 (77.87±0.81%), F4 (85.23 ± 0.98%). The type of oil can affect the characterization physical properties and dissolution of fenofibric acid SNEDDS. The best formula was shown by F2, which was a formula containing castor oil as an oil component.

Keywords: dissolution, fenofibric acid, castor oil, SNEDDS.

References

Alagona, P. 2010. Fenofibric Acid: A New Fibrate Approved for Use in Combination with Statin for the Treatment of Mixed Dyslipidemia. Vascular Health and Risk Management 6 (1): 351–62.
Amidon, G. L., Hans, L., Vinod, P., Shah and John, R. C. 1995. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists 12(3):413-420
Ananthan, Sand and Reddy, K. V. N. 2018. Solubility Enhancement Techniques of Poorly Water Soluble Drug. International Journal of Science and Research (IJSR) 7 (12): 553–60.
Bali, V., Mushir, A and Javed, A. 2010. Study of Surfactant Combinations and Development of a Novel Nanoemulsion for Minimising Variations in Bioavailability of Ezetimibe. Colloids and Surfaces B: Biointerfaces 76 (2): 410–20.
Baloch, J., Muhammad, F. S., Hafiz, S. S., Maria H. K., Gul, M. K., Sarwat, J., Muhammad, R., Muhammad, T. C., Masoom, Y and Gul, S. 2019. Self-Nanoemulsifying Drug Delivery System (Snedds) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and in Vivo Evaluation. Medicina (Lithuania) 55 (5): 1–13.
Basalious, E. B., Nevine, S and Shaimaa, M. B. 2010. SNEDDS Containing Bioenhancers for Improvement of Dissolution and Oral Absorption of Lacidipine. I: Development and Optimization. International Journal of Pharmaceutics 391 (1–2): 203–11.
Canapi, E.C, Agustin, E. A., Moro, E., Pedrosa, J. M., Luz and Bendana, J. 1996. Coconut Oil, in Bailey’s Industrial Oil and Fat Products. 5th ed. New York: Wiley-Inerscience.
Čerpnjak, K., Alenka, Z., Mirjana, G and Franc, V. 2013. Lipid-Based Systems as a Promising Approach for Enhancing the Bioavailability of Poorly Water-Soluble Drugs. Acta Pharmaceutica 63 (4): 427–45.
Daar, J., Ahmad, K., Jallat, K., Amjad, K and Gul, M. K. 2017. Studies on Self-Nanoemulsifying Drug Delivery System of Flurbiprofen Employing Long, Medium and Short Chain Triglycerides. Pakistan Journal of Pharmaceutical Sciences 30 (2): 601–6.
Date, A. A, Desai, N and Nagarsenker, M. 2010. Review Self-Nanoemulsifying Drug Delivery Systems : Formulation Insights, Applications and Advances. Nanomedicine 5 (12):10.
Dijkstra, A. J and Duijn, G. V. 2015. Vegetable Oils: Oil Production and Processing. Encyclopedia of Food and Health. 1st ed. Elsevier Ltd.
Grove, M., Pedersen, G. P., Nielsen, J. L and Müllertz, A. 2005. Bioavailability of Seocalcitol I: Relating Solubility in Biorelevant Media with Oral Bioavailability in Rats - Effect of Medium and Long Chain Triglycerides. Journal of Pharmaceutical Sciences 94 (8): 1830–38.
Gursoy, R. N and Simon, B. 2004. Self-Emulsifying Drug Delivery Systems (SEDDS) for Improved Oral Delivery of Lipophilic Drugs. Biomedicine and Pharmacotherapy 58 (3): 173–82.
Kim, K. S., Jeong, H., Kim, S, Giu, J and Dong, W. 2016. Effect of Magnesium Carbonate on the Solubility, Dissolution and Oral Bioavailability of Fenofibric Acid Powder as an Alkalising Solubilizer. Archives of Pharmacal Research 39 (4): 531–38.
Kotta, S, Khan, A. W., Pramod, K., Ansari, S. H., Sharma, R. K and Ali. J. 2012. Exploring Oral Nanoemulsions for Bioavailability Enhancement of Poorly Water-Soluble Drugs. Expert Opinion on Drug Delivery 9 (5): 585–98.
Makadia, H. A., Bhatt, A., Ramesh, B., Parmar., Jalpa, S., Paun, H. M and Tank. 2013. Self-Nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Asian Journal Pharmaceutical Research 3 (1).
McClements, D.J. 2012. Requirements for Food Ingredient and Nutraceutical Delivery Systems. Encapsulation Technologies and Delivery Systems for Food Ingredients and Nutraceuticals.
Nasr, A., Gardouh, A and Ghorab, M. 2016. Novel Solid Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) for Oral Delivery of Olmesartan Medoxomil: Design, Formulation, Pharmacokinetic and Bioavailability Evaluation. Pharmaceutics 8 (3).
Patel, J., Patel, A., Raval, M and Sheth, N. 2011. Formulation and Development of a Self-Nanoemulsifying Drug Delivery System of Irbesartan. Journal of Advanced Pharmaceutical Technology and Research 2 (1): 9–16.
Piorkowski, D. T and McClements, D. J. 2014. Beverage Emulsions: Recent Developments in Formulation, Production, and Applications. Food Hydrocolloids 42: 5–41.
Rath, N, P., Haq, W and Balendiran, G. K. 2005. Fenofibric Acid. Acta Crystallographica Section C: Crystal Structure Communications 61 (2): 81–84.
Senapati, P. C., Sahoo, S. K and Sahu, A. N. 2016. Mixed Surfactant Based (SNEDDS) Self-Nanoemulsifying Drug Delivery System Presenting Efavirenz for Enhancement of Oral Bioavailability. Biomedicine and Pharmacotherapy 80: 42–51.
Singh, B., Beg, S., Khurana, R. K., Sandhu, P. S., Kaur, R and Katare, O. P. 2014. Recent Advances in Self-Emulsifying Drug Delivery Systems (SEDDS). Critical Reviews in Therapeutic Drug Carrier Systems 31 (2): 121–85.
Syukri, Y., Martien, R., Lukitaningsih, E and Nugroho, A. E. 2018. Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of Andrographolide Isolated from Andrographis Paniculata Nees: Characterization, in-Vitro and in-Vivo Assessment. Journal of Drug Delivery Science and Technology 47: 514–20.
Suhery, W. N., Sumirtapura, Y. C and Mudhakir, D. 2020. Development and Characterization of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Formulation for Enhancing Dissolution of Fenofibric Acid. J Res Pharm. 24(5): 738-747
Windriyati, Y. N, Sumirtapura, Y.C and Pamudji. J. S. 2019. Dissolution Enhancement and Physicochemical Characterization of Fenofibric Acid in Surface Solid Dispersion with Croscarmellose Sodium. Marmara Pharmaceutical Journal 23 (2): 315–25.

The Effect of Oil Type on the Characterization of Physical Properties and Dissolution of the Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Fenofibric Acid

Abstract

References