Gelatin Hasil Transformasi Kulit Ikan Patin (Pangasius hypohthalmus) sebagai Gelling Agent dalam Formulasi Gel Piroksikam
Kata Kunci:
Gel, Piroksikam, Gelatin, Pangasius hypophthalmusAbstrak
Piroksikam merupakan obat antiinflamasi nonsteroid yang efektif, tetapi memiliki efek samping yang serius jika diberikan secara oral. Penelitian ini dilakukan untuk memformulasi piroksikam dalam bentuk sediaan gel dengan menggunakan gelatin hasil transformasi kulit ikan patin (Pangasius hypophthalmus) sebagai bahan pembentuk gel. Penggunaan bahan hasil transformasi kulit babi dan sapi tidak dapat diterima oleh sebagian penganut agama. Penelitian ini bertujuan untuk memformulasi gel piroksikam dan mengetahui pelepasan piroksikam dari gel pada berbagai konsentrasi yaitu 0,75, 0,875, dan 1%, sedangkan produk inovator (F4) digunakan sebagai pembanding. Evaluasi yang dilakukan adalah organoleptik, homogenitas, pH, daya sebar, dan profil pelepasan. Uji pelepasan piroksikam dari formula gel dilakukan menggunakan alat disolusi tipe dayung yang dimodifikasi dan dilengkapi dengan membran kulit telur yang diletakkan pada piringan logam. Kadar piroksikam yang terlarut diukur dengan spektrofotometer UV pada λmax 356,4 nm. Pelepasan piroksicam dari gel formula F1, F2, F3, dan F4 mengikuti model kinetika orde nol. Nilai efisiensi disolusi dan T90 dari formula F1, F2, F3, dan F4 menunjukkan perbedaan yang sangat signifikan (p < 0,01), sedangkan laju disolusi menunjukkan perbedaan yang signifikan (p < 0,05). Semua formula memenuhi persyaratan sediaan gel kecuali karakteristik daya sebar.
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